Friday, November 29, 2019

Diversity In Toons Essays - Kingdom Hearts Characters, Piglet

Diversity In Toons In comparing children's programs for their use of cultural diversity I watched several segments of Rugrats, Winnie the Pooh, and Out of the Box. The animated programs, Rugrats and Winnie the Pooh, dealt with diversity in much the same way. Out of the Box, however, was put together on a different level. The Rugrats is a delightful cartoon about a group of adventurous babies that are always getting into one thing or the other. The baby's personalities are all quite different and ones weakness is offset by another ones strengths. Tommy, a very intelligent, articulate, courageous, and compassionate one year old is the leader of the group. His best friend Chuckie is a neurotic two-year-old who is afraid of his own shadow! Phil and Lil, the twins from next door, look alike, think alike, and would follow Tommy Pickles to the ends of the earth. They love the adventures, the messier and scarier the better! They are the lovers of mud-pies, bugs, and moldy things. Tommy's older cousin, Angelica, rounds out the group as the spoiled rotten princess who bullies the babies and manipulates the adults. Angelica has one friend, other than the babies, a black girl her age named Susie who she is always in competition with. The adults in the show represent even more diverse groups. Tommy's Dad, Stu, is an absent-minded toy inventor who loves his son dearly but tends to let his preoccupation with his inventions rule his world. His wife, Didi, is your classic, practical, overprotective mother that is on a quest to be the world's most perfect mother. She, however, is completely unaware of just how much Tommy knows and understands. Tommy's Uncle Drew is a boring investment banker that dotes on Angelica and seriously believes that she is an angel. Aunt Charlotte, on the other hand, is the professional corporate type workaholic and assuages her guilt by lavishing Angelica with undeserved gifts. Betty Deville, Didi's best friend and the twin's mother, is a loud, big, and friendly woman who lives for her twins. Her husband, Howard, is the quiet techno-nerd type that hangs in the background. Chuckie's Dad, Chaz (Charles Sr.) Finster is a whiny, neurotic worrier and a single parent. After a few seconds with Chaz it's obvious where Chuckie gets his personality. Last, but certainly not least , there's Stu's and Drew's Dad and Tommy's Grandpa. Grandpa is the cantankerous old geezer with a soft spot for his grandson. He tends to over indulge the babies and lives somewhere between the adult and Rugrat world. The second animated show, Winnie the Pooh, also has a cast of diverse characters. There's Pooh, a wonderful bear with a huge heart and a little brain. He has a happy and helpful nature and an innocence that makes him a very straightforward character. Pooh bear's best friend is Piglet. He's portrayed as a small a fearful type but is actually the most courageous creature in the 100-Acre Wood. Piglet can face anything with his friend Pooh at his side. Next there is Eeyore my personal favorite. Eeyore is a gloomy-Gus donkey that pretends not to care what anyone thinks. He's the group's resident pessimist who secretly loves when his friends appreciate him. Tigger is the bouncy, one of a kind Tiger that has a wonderful self-image and is brimming with enthusiasm. The last main character is Rabbit. Rabbit is the solid citizen that always has a plan for something or other, usually to teach Tigger some kind of lesson. He loves nothing more than to tend his garden and keep everyone in order, al though Tigger usually is in his way! Both Rugrats and Winnie the Pooh are geared for young children. They do, however, appeal to the older segment of children. Discriminations and prejudices about race and ethnic groups are not openly portrayed and addressed they are, however, present. In my opinion the interaction of the characters deal with different types of diversity every day. Whether it's the way in which the characters interact with each other or the choices they make when they find themselves faced with something new and different. I don't believe that this type of programming would confuse a child because it

Monday, November 25, 2019

Eisenhowers Warnings essays

Eisenhowers Warnings essays In Eisenhowers Farewell Address, the president gave warnings to his people regarding the influence of "the military-industrial complex." After engaging in three of the four major wars of the century, America arose as the strongest nation. In response to the worlds turmoil, America built up the armament industry. The nation began to prepare for war before the threat arose instead of waiting until wartime to make ready the weapons. There was also a technological revolution during these post-war years. During this revolution, the government began to conduct and direct research. With these two advances in American history, Eisenhower felt there were a number of possible negative outcomes, and therefore, he warns his people about the distruction that these new develops have the potential to cause. Some of the dangers of the complex that he mentions in his speech include: rise of misplaced power, endangering our liberties or democratic policies, public becoming a captive of a scientific-technological elite, and becoming a community of dreadful fear and hate. Eisenhower feels that the countrys move to preparedness for war is taking them farther away from peace. In his perfect world, people would not solve their conflicts by fighting, but by peacefully negotiation. I think that his view is admirable and would probably be the best possible way to deal with things, but I do not find it to be all that realistic. The possible scenarios and problems that he came up with are all possible, and I agree that they are all probable, but I do not feel like peace among all nations will ever exist until we are at war with other worlds. People need war and conflict to survive and if we take that need away, we will in essence be defying nature and that seems to also end in anarchy. Is it better to be in turmoil as one nation or as an entire universe? ...

Thursday, November 21, 2019

The Commodification of Human Organs Essay Example | Topics and Well Written Essays - 3250 words

The Commodification of Human Organs - Essay Example In short, these programmes have failed to make more organs available for transplantation. They are just unable to meet the requirements of the patients' needs for donated organs. On the face of this dearth of available organs that could have saved or qualitatively enhanced suffering human life, a more sympathetic attitude has long been entertained to create proposals for alternative procurement of organs. This includes provision of compensation to the organ donors. However, this has become an open secret in practice since there is an ongoing debate about the ethical pros and cons of this phenomenon and there are rigorous ethical norms exercised by the authority in this matter. The healthcare professionals who are involved in this area are actually in a dilemma, following ethics strictly leads almost to no practice, and hiding the truth is unethical. This work deals with this dilemma, and tries to critically examine this issue from this author's perspective. In the latter half of the 20th century, the possibility of transplanting organs became real. New advances in immunology and understanding of the mechanism of organ transplantation lead to development of new technologies for transplantation and support for the transplanted organ that, otherwise, would have been rejected by the recipient. Meanwhile, the medical profession accepted the concept of brain death that indicated a point at which death of an individual might officially be declared. Since organ transplantation has become feasible, many ethical issues and questions have arisen. The most important of them was the propriety of arbitrarily redefining death so as to make organ retrieval more easily possible. Gradually, as the science and technique advanced, more and more questions grounded on ethics started coming up. The history also indicates a future (Baker LR., 2000). The rate science is advancing, in the near future, the dream of growing organs from stem cells may materialize. In that case, naturally, the ethical issues encircling transplanting organs from newly dead or from living donors may become irrelevant. Regrettably, this is not the case at present. Ethical rigorousness in preventing financial exchanges around an available organ may, therefore, lead to a situation where some critically ill patients in need of an organ transplant would meet certain, agonizing, and perhaps unnecessary death (Dworkin R., 1993). At this point in time, some of the earlier ethical objections and quandaries, such as, whether organ or tissue donation is ethically permissible in the first place or whether selections made by groups of people were legitimate option, have become irrelevant largely, either because finding, advancement in science, or public consensus has resolved them. Despite this, some very critical ones remain still. These are not around the substantive question of the probity of transplantation in the first place. Ethics have accepted the legitimacy of transplantation very much, and now the probe is on the issues of allocation. In fact, among the most important of the issues that is to be dealt with in relation to the ethics of organ transplantation are the questions dealing with the mode, process, or rules of organ allocation, not to individual patients per se but allocation to centres which in turn allocate to individuals (English, V. and Sommerville, A., 2003). Death

Wednesday, November 20, 2019

The Joy Luck Club (novel) Essay Example | Topics and Well Written Essays - 750 words

The Joy Luck Club (novel) - Essay Example She not only accomplishes the goal of her mother on her behalf, but also gets to learn more about her mother as a result of the unique experience of reuniting with her long lost and never seen before half-sisters. Jing-mei and Waverly share the feeling of regret of having lost ties with their indigenous Chinese culture in their attempts to identify themselves with the Americans. Jing-mei and Waverly share the same cultural differences with their respective mothers which also happen to be the cause of misunderstandings between the daughters and the mothers. On one hand, Jing-mei does not find her mother as supportive, understanding, and leveraging as she would like her to be as an American and on the other hand, Waverly is uncomfortable with and afraid of the criticism that her mother offers to Waverly’s fiance Rich; â€Å"But I worried for Rich. Because I knew my feelings for him were vulnerable to being felled by my mother’s suspicions, passing remarks, and innuendosà ¢â‚¬  (Tan 175). ... Waverly seems to be setting the standards and Jing-mei seems to be knocked out mostly. This can be fundamentally attributed to the fact that rather than realize her own potential and qualities, Jing-mei keeps comparing herself to Waverly all the time. Waverly inherits invisible strength from her mother that she uses to strategize, and when she does that to Jing-mei, Jing-mei feels downplayed. The very strength makes Waverly develop a sense of competitiveness because of which, she becomes Jing-mei’s rival and insults her at the dinner of Suyuan’s New Year in front of others. Jing-mei finds Waverly too difficult and offensive to talk to. She explains this in these words, â€Å"I felt like screaming. She could be so sneaky with her insults. Every time I asked her the simplest of tax questions, for example, she could turn the conversation around and make it seem as if I were too cheap to pay for her legal advice† (Tan 204). The Episode of crabs illustrates that Waver ly wants only the very best and is intelligent enough to choose it while Jing-mei is not which is why she does not know what are the best qualities to look for in a crab and also she gets belittled by Waverly at the dinner. Jing-mei’s relation toward Waverly changes over time as she reflects upon her own weaknesses. She realizes that in her attempt to keep competing with Waverly, she has been finding herself coming up short; â€Å"I turned on the water to wash the dishes. And I no longer felt angry at Waverly. I felt tired and foolish, as if I had been running to escape someone chasing me, only to look behind and discover there was no one there† (Tan 207). In spite of her weaknesses and insecurities, Jing-mei has a lot of room for improvement and she does improve as the novel

Monday, November 18, 2019

Step 1 of 4 Paper Essay Example | Topics and Well Written Essays - 250 words

Step 1 of 4 Paper - Essay Example How information flows from level to level in a company is also determined by the organizational structure. Decisions flow from top to down in a centralized structure while in a decentralized structure, making decisions is done at various different levels (Wailgum, 2007).Decentralized decision making should be preferred by managers because it gives the opportunity to the employees to participate in decision-making. This makes them have a sense of ownership of the company and, therefore, give their best. Companies can streamline their operations if they establish a hierarchical structure whose chain of command is clear. The organizational leadership structure should be able to provide direct supervision and regular feedback from employees (Lu, 2014). Corporate decision making allows all stakeholders be involved in decision making and their contributions valued. Autocratic leadership makes managers the sole decision makers and deters innovativeness as the creative employees do not get a room of implementing or sharing their ideas. Therefore, participative leadership which boosts the morale of employees because their contribution to the decision-making process is appreciated should be adopted by company heads. The success of any business is determined by the innovativeness of the company. Through innovation, companies bring into the market new products and services. Innovative methods assist companies reduce costs of operation and enhance customer satisfaction through quality improvement. Innovativeness can only be realized if creative employees are given room to share and implement their ideas. Leadership style used should support creativity and innovativeness among the employees to enhance the performance of their companies. Gilmore (2014) observes that the state of the art technology and network design has enabled Wal-Mart to track and predict inventory levels, manage customer service response logistics and relationships, develop more efficient

Saturday, November 16, 2019

Origins of Tissues Macrophages

Origins of Tissues Macrophages Ryan Lewis    Discuss current ideas about the origins of tissue macrophages and whether these origins influence the subsequent functions of macrophage Graphical Abstract Figure Legend: This figure highlights possible tissue macrophage origins and their development pathways. The essay discusses contradicting findings in the literature, involving three different publications; Sheng et al, 2015 (blue pathway), Hoeffel et al, 2015 (red pathway) and Perdiguero et al, 2015 (green pathway) which are shown in the figure. Cell positions relate to the time point they are established during embryonic development. Positions of yolk sac and foetal liver are also related to the times they are developed. Introduction In the late 19th century Ilya Metchnikoff discovered macrophages (Tauber, 2003) and since then our understanding of the immune system and its complexity has progressed to a stage where the macrophage is no longer as simple as was originally depicted by Metchnikoff. Although much more is known about tissue specific macrophages and their functions, the origins of these macrophages are less well understood including how their origins relate to the functions they have within specific tissues. This essay aims to address the current ideas about the origins of tissue macrophages and whether these origins influence the subsequent functions of macrophages. Macrophage Discovery and History As previously mentioned Metchnikoff discovered the macrophage late in the 19th century (Tauber, 2003). Metchnikoff published a paper talking about phagocytic cells he had observed in frogs, he described the phagocytic cells as being involved in host defence but also the clearing of dead and dying cells (Gordon, 2007). Mechnikoff then discovered the presence macrophages in starfish, which dont have a vascular system, which led him to the discovery of tissue-resident macrophages (Gordon, 2007). Metchnikoff received the Nobel prize for his studies on cellular immunity to infection in vertebrates which he shared with Paul Ehrlich who discovered humoral immunity (Gordon, 2007). It took roughly 80 years after Metchnikoffs discovery before the origin of the tissue macrophage was uncovered. It was proposed that tissue macrophages originated from circulating monocytes in the blood (van Furth and Cohn, 1968), this theory has persisted for the last 40 years however from recent studies we know t hat this is not the primary origin of the tissue macrophage. Shortly after the theory that tissue macrophages originated from circulating monocytes was proposed, it was discovered that tissue macrophages and monocytes are heterogenous and their heterogeneity is conserved in humans and mice (Gordon and Taylor, 2005). The discovery of monocyte subsets followed shortly after in 1983, which supported the theory that tissue macrophages originated from circulating monocytes (Yona and Jung, 2009). The theory that tissue macrophages are derived from circulating monocytes has been the prevailing view until very recently partly due to the arrival of advanced techniques including; fate mapping and ionizing radiation. In the last 5-6 years, many definitive publications have redefined our understanding of the origins of tissue macrophages (Epelman et al, 2014). Recent studies have shown that many tissue macrophages are established during embryonic development and continually self-replenish into adulthood independently of any input from circulating monocytes in the blood (Epelman et al, 2014; Ginhoux et al, 2010; Hashimoto et al, 2013; Yona et al, 2013). Tissue Macrophage Heterogeneity and Function Tissue macrophage have a huge degree of heterogeneity which reflects upon the specialization of their functions in different tissues and locations (Gordon and Taylor, 2005). Macrophage heterogeneity is required to ensure the tissue macrophage has the most effective phenotype to tackle its specific microenvironment, this is particularly important in the gut. Tissue macrophages in the gut isolated from the lamina propria have a unique phenotype characterised by high phagocytic and bactericidal activity but very poor production of pro-inflammatory cytokines which makes them perfectly suited to their microenvironment (Gordon and Taylor, 2005). There are many specialised tissue macrophages that have very distinct functions including; osteoclasts in the bone which breakdown bone deposits for bone remodelling, alveolar macrophages (dust cells) in the lung that break down foreign material and pathogens, and microglia in the brain which play a role in neuronal development homeostasis and the recovery from pathology (Boyce et al, 2008; Rubins, 2003; Prinz et al, 2014). The theory that tissue macrophage populations are replenished from circulating monocytes in the blood is somewhat true but the most diverse tissue macrophages such as microglia, alveolar macrophages and osteoclasts are replenished through self-renewal and proliferation (Yona and Jung, 2009). There is a substantial number of studies discussing whether macrophages originating from monocytes in the blood can differentiate into resident tissue macrophages. In most cases the monocyte subset that the macrophage originated from determines its ability to differentiate into a specialized resident tissue macrophage, this is particularly true in the lung as studies have shown only Ly6Clo, not Ly6Chi, monocytes have the ability to differentiate into enchymal lung macrophages (Landsman et al, 2007). In regards to the more complex and specialised alveolar macrophages in the lung, studies have shown that these macrophage s require a parenchymal lung macrophage intermediate (Landsman and Jung, 2007). Circulating monocytes in the blood were long believed to be the origin of specialised tissue macrophages but recent evidence has shown that this is incorrect and proven that many of these tissue macrophage populations are developed long before birth (Epelman et al, 2014). Origins of Tissue Macrophages Macrophages are first observed during embryonic day 6.5 and are produced in the yolk sac during what is termed as primitive haematopoiesis (Epelman et al, 2014). During this early stage in development macrophages are the only immune cell produced due to restricted progenitors in the yolk sac. During embryonic days 8.5 10.5 hematopoietic stem cells (HSCs) emerge from the aorta-gonad meso-nephros (AGM) and give rise to all immune lineages (Epelman et al, 2014). At embryonic day 10.5 HSCs migrate from the AGM to the foetal liver, the foetal liver then becomes the major hematopoietic organ until birth. Only after birth do bone marrow HSCs become the primary progenitors and produce all immune lineages (Orkin and Zon, 2008). Microglia are the only tissue macrophages that are established in the yolk sac and are self-maintained through-out adulthood, all the other tissue macrophages are established from embryonic day 14.5 to birth and either self-maintained by proliferation or replenished b y HSCs in the bone marrow (Ginhoux et al, 2010; Sheng et al, 2015). The arrival of fat-mapping techniques have enabled researchers to precisely track embryonic macrophage populations into adulthood, giving an insight into the relationship between resident tissue macrophages and circulating blood monocytes (Epelman et al, 2014). As previously discussed, microglia are the only tissue macrophage originating from the yolk sac and arise before embryonic day 8 (Ginhoux et al 2010). Fate mapping analysis was used to determine that the origin of microglia was the primitive myeloid precursors in the yolk sac and also proved that microglia are self-maintained independently of any circulating blood monocytes (Ginhoux et al, 2010). There is also evidence that Langerhans cells originate from the yolk sac but only partially (Sheng et al, 2015). The fate mapping study by Sheng proved that microglia and Langerhans cells were the only tissue macrophages that originate from yolk sac precursors and th at most adult tissue macrophages originate from a second wave of haematopoiesis driven by HSCs. (Sheng et al, 2015). The number recent of publications concerning tissue macrophage origins is staggering and is most likely attributed to the arrival of fate mapping techniques. With the large surge of new studies regarding tissue macrophage origins it is important that a clear understanding is generated but this is not always possible with such a complicated subject. Contrasting Studies into Tissue Macrophage Origins There are a few recent studies concerning tissue macrophage origins which are particularly interesting. Sheng (Sheng et al, 2015) arrived at the conclusion that most tissue macrophages originate from HSCs however there are a few publications which contradict Shengs findings. Perdiguero concluded that yolk sac derived erythro-myeloid progenitors, were origin of almost all tissue macrophages which contrasts greatly with Shengs observations. (Perdiguero et al, 2015). Perdiguero also concluded that microglia were derived from erythro-myeloid progenitors rather than primitive yolk sac progenitors that was observed by Sheng, although both do come from the yolk sac (Perdiguero et al, 2015; Sheng et al, 2015). Perdiguero predicted that almost all other tissue macrophages originated from erythro-myeloid progenitors (Perdiguero et al, 2015; Sheng et al, 2015). A study by Hoeffel aligned well with Perdigueros observations but Hoeffel observed that primitive yolk sac progenitors gave rise to mic roglia rather than erythro-myeloid progenitors that was observed by Perdiguero (Hoeffel et al, 2015; Perdiguero et al, 2015). As well as the difference in the development of microglia, Hoeffel predicted that erythro-myeloid progenitors migrated to the foetal liver, giving rise to foetal monocytes which were then responsible for the production of tissue macrophages. (Hoeffel et al, 2015). Each of these 3 examples also propose a separate proposed major path of ontogeny and differentiation to adult tissue macrophage state. Perdiguero proposes erythro-myeloid progenitors from the yolk sac as the major precursor of tissue macrophages, Heoffel proposes erythro-myeloid progenitors from the foetal liver, as foetal monocytes, as the major precursor and, Sheng proposes that HSCs from the foetal liver are the major precursor (Perdiguero et al, 2015; Hoeffel et al, 2015; Sheng et al, 2015; Guinhoux and Guilliams, 2016). Although the observations made by Sheng are profoundly different to those m ade by Perdiguero and Hoeffel it could be down to the fate mapping technique they used. The model they used is not adapted to distinguish between late erythro-myeloid progenitors and foetal HSCs which has clearly effected the conclusion they have come to (Guinhoux and Guilliams, 2016). Although fate mapping has great potential in advancing our knowledge of cellular ontogeny there are certain limitation that come with it and these limitations must be considered when designing experiments and analysing data (Guinhoux and Guilliams, 2016). Do Tissue Macrophage Origins Matter? Determining the origins of tissue macrophages may be valuable for furthering our knowledge and understanding of their development but do their origins have any influence in determining their function? As well as ontogeny, diversity in the functions of tissue macrophages can also be attributed to the local signals received by the macrophages. These local changes can drive the expression of unique transcription factors which in turn lead to different functions (Lavin et al, 2015). There is a lot of evidence to suggest that the tissue macrophages microenvironment can alter its function, the plasticity of tissue macrophages allows them to adjust their functions to inflammatory events (Lavin et al, 2015). Using ionizing radiation most embryonic-derived tissue macrophages can be eliminated, they can then be replaced with donor-derived bone marrow progenitors to determine if the wild type state of the tissue can be restored. Using this technique, studies have proven that bone marrow progeni tors can completely restore the enhancer profile and transcriptional programme of the embryonic-derived tissue macrophages that were eliminated (Lavin et al, 2015). A very recent study has shown that yolk sac macrophages, foetal liver monocytes and adult bone marrow monocytes can all successfully differentiate into alveolar macrophages in the lung after the removal of the native alveolar macrophages using ionizing radiation (van de Laar et al, 2016). The study also showed that other already developed tissue macrophages, liver, peritoneal and colon macrophages cannot successfully differentiate into alveolar macrophages in the lung. This finding suggests that the plasticity of the mononuclear phagocyte system is at its largest during the precursor stage and after differentiation to tissue-resident macrophages no further phenotypic changes of macrophage types can take place (van de Laar, 2016). Perhaps the most interesting finding from this study is that the alveolar macrophages differ entiated from yolk sac macrophages, foetal liver monocytes and bone marrow monocytes were still able to self-maintain and prevent alveolar proteinosis (van de Laar, 2016). Similar results have also been observed with Kupffer cells. Kupffer cells were eliminated from the liver using diphtheria toxin-mediated depletion allowing its niche to become vacant. Observations showed that circulating monocytes can engraft the liver and adopt the transcriptional profile of the eliminated Kupffer cells and also become long-living self-renewing cells like their eliminated counterparts (Scott et al, 2015). These new findings question whether the origin of tissue macrophages is truly important to their function as the progenitors and monocytes tested have all been able to restore the tissues lost macrophages successfully without any loss of function. Conclusion Although determining the origins of tissue macrophages and other members of the immune system is important for the progression of our knowledge it remains to be seen whether the actual origins have any implications on the function of the tissue macrophages. The techniques used in the publications discussed are still very new and still require refinement, I believe further refinement of the techniques will enable a more detailed and accurate description on the origins of tissue macrophages and the role the origins play in their function. References       BOYCE, B.F., YAO, Z. XING, L. 2009Osteoclasts have multiple roles in bone addition to bone resorption.Critical Reviews in Eukaryotic Gene Expression, 19.3, 171-180 EPELMAN, S., LAVINE, K.J. RANDOLPH, G.J. 2014Origin and functions of tissue macrophages.Immunity, 41.1, 21-35 GINHOUX, F., GRETER, M., LEBOEUF, M., NANDI, S., SEE, P., GOKHAN, S., MEHLER, M.F., CONWAY, S.J., GUAN NG, L., STANLEY, E.R., SAMOKHVALOV, I.M. MERAD, M. 2010Fate mapping analysis reveals that adult microglia derive from primitive macrophages.Science, 330.6005, 841-845 GUINHOUX, F. GUILLIAMS 2016Tissue-resident macrophage ontogeny and homeostasis.Immunity, 44.3, 439-449 GORDON, S. 2007The macrophage: past, present and future.European Journal of Immunology, 37, 9-17 GORDON, S. TAYLOR, P.R. 2005Monocyte and macrophage heterogeneity.Nature Reviews: Immunology, 5.12, 953-964 HASHIMOTO, D., CHOW, A., NOIZAT, C., TEO, P., BEASLEY, M.B., LEBOEUF, M., BECKER, C.D., SEE, P., PRICE, J., LUCAS, D., GRETER, M., MORTHA, A., BOYER, S.W., FORSBERG, E.C., TANAKA, M., VAN ROOIJEN, N., GARCIA-SASTRE, A., STANLEY, E.R., GINHOUX, F., FRENETTE, P.S. MERAD, M. 2013Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.Immunity, 38.4, 792-804 HOEFFEL, G., CHEN, J., LAVIN, Y., LOW, D., ALMEIDA, F.F., SEE, P., BEAUDIN, A.E., LUM, J., LOW, I., FORSBERG, E.C, POIDINGER, M., ZOLEZZI, F., LARBI, A., NG, L.G., CHAN, J.K., GRETER, J.K., BECHER, B., SAMOKHVALOV, I.M., MERAD, M. GINHOUX, F. 2015C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages.Immunity, 42.4, 665-678 LANDSMAN, L., VAROL, C. JUNG, S. 2007Distinct differentiation potential of blood monocyte subsets in the lung. Journal of Immunology, 178.4, 2000-2007 LANDSMAN, L. JUNG, S. 2007Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages.Journal of Immunology, 179.6, 3488-3494 LAVIN, Y., MORTHA, A., RAHMAN, A. MERAD, M. 2016Regulation of macrophage development and function in peripheral tissues.Nature Reviews: Immunology, 15.12, 731-744 ORKIN, S.H. ZON, L.I. 2008Haematopoiesis: an evolving paradigm for stem cell biology.Cell, 132, 631-644 PERDIGUERO, E.G., KLAPPROTH, K., SCHULZ, C., BUSCH, K., AZZONI, E., CROZET, L., GARNER, H., TROUILLET, C., DE BRUIJN, M.F., GEISSMANN, F. 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JUNG, S. 2013Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.Immunity, 38.1, 79-91 YONA, S. JUNG, S. 2009Monocytes: subsets, origins, fates, and functions. Current Opinion in Hematology, 17.1, 53-59

Wednesday, November 13, 2019

The Atkins Diet Versus Low-Fat Diets Essay -- Health Nutrition Diet Ex

The Atkins Diet Versus Low-Fat Diets   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  The Atkins diet and the USDA recommended low-fat diet seem to be on the opposite sides of the diet spectrum. These two diets have many differences and no apparent similarities, other than the goal of losing weight. These differences include the results of the diets, possible side effects, and the theories behind the diets. The Atkins diet recommends reducing carbohydrate intake in order to lose weight. Conversely, the low-fat diet recommends reducing caloric intake to lose weight; especially the calories from fat. The Atkins diet and the low- fat diet differ in the methods behind their diets, the results that participants experience while on the diet and the possible side effects linked to the diet.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  The methods behind the Atkins diet and the low-fat diet differ extensively. The Atkins diet is based on the theory that a reduction in carbohydrate intake will lower the dieter’s body weight. The recommended amount of carbohydrates for this diet is 20 grams for the first phase of the diet. During the second stage of the diet, participants are encouraged to increase their carbohydrate intake by 5 grams every week until their weight loss has stopped. Usually the intake of carbohydrates remains under 30 grams a day for the duration of the diet. The rest of the diet consists of an unlimited amount of protein and fat. On the other hand, the low-fat diet restricts caloric intake about 2,000 calories (depending on your age, sex, and height) in order to lose weight. Within the dieter’s restricted amount of calories; 30% of the overall calories can be from fat, 10% from protein, and 60 % from carbohydrates. On a 2,000 calorie diet, this wo... ...n negative side effects due to the lack of fiber through fruits, vegetables and grains; whereas those on low-fat diets have shown the positive side effect of a lowered risk of heart disease.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  The Atkins diet and the low-fat diet show differences in their method of weight loss, the short-term and long-term results of their diet and the side effects that are caused by the method of the diet. The Atkins diet emphasizes the reduction of carbohydrates from the diet in order to lose weight; whereas the low-fat diet emphasizes the reduction of calories, especially those high in fat. The Atkins method seems to cause more weight loss than the low-fat diet within the first 3-6 months but shows similar loss after 12 months. But this increased weight loss early in the diet is accompanied by more negative side effects than the low- fat diet.

Monday, November 11, 2019

Lean On Me Film Review Essay

In the film Lean on Me, Joe Clark, played by Morgan Freeman, took on the responsibility of being the principle for a troubled inner-city high school. The students at this high school were mainly minority children, faced by issues of poverty, drugs, and racism everyday. The state of New Jersey claimed that this school was heading nowhere but down and that the teachers were unable to teach the children the basic skills they needed to survive in the world. I feel the causes of the schools poor quality was to the lack of money & funds they receive from the state which lead to poor programming. The children whom attended the school had a lack of motivation and direction. They were unsure as to what they wanted to achieve with their lives. They needed to be inspired by their teachers, and their families. However, as seen in this film, children in the inner-city setting often never find the inspiration and direction they need to succeed. Many of them have parents that do not want to play an active role in the lives of their children. I feel that in the case of this film, Joe Clark?s authoritarian methodology of administering was very effective. This school and the children who attended it needed someone to ?take charge?, and build it back up to shape. He first kicked out the ?trouble students?, then he cleaned the halls of the graffiti, then he chained the doors to keep the drug dealers out. He gave students confidence and inspiration to succeed. He gave them a common goal, to ?prove the state wrong?. He enforced in their minds that they were not ignorant and they were capable of anything. By insisting they learn the school song he gave them a sense of pride. I feel that Joe Clark did just what the school and most importantly the students needed to ?turn the school around?. In the end, his methods of leadership worked, for the students achieved just what they had set out to do, pass the basic skills test given by the state. The women who fought Joe Clark?s methodology, was played by Lynne Thigpen. She was portrayed as ?wench?, who was demanding on the city to get rid of Joe Clark because he chained the school doors and was in violation of the cities fire code. However, I feel she was really just upset because he  expelled the ?problem children? out of the school, one of whom was her son. Instead of blaming herself as a parent for the failure of her son, she turned the blame on the school system and those who run it. While some critics would say that she was being portrayed in a positive light, as being a strong and determined black women. I feel that is false, I feel she is being portrayed as ignorant and arrogant and just wants revenge for something that was her own fault because she is not being an attentive and responsible parent. I also feel that the music plays an important role in this film. The music in the film is what gives the children hope and pride. The title of the movie is from the song ?Lean on Me?, written by Bill Withers. This song has lyrics that bring hope to the children. ?Some times in our lives we all have pain, we all have sorrow, but if you are wise we know there is always tomorrow. Lean on me, when your not strong, and I?ll give you hope, I?ll help you carry on.? It is relating to the students by saying we all face struggles, but we need to have hope that we can survive, and sometimes we need to get support and inspiration from others in order to stay strong and succeed. This song reminds these children that they are not alone and they can achieve anything if they put their minds to it. I feel that this song explains the theme of the movie, in the face of trouble anyone can succeed as long as they are motivated and try their hardest, and they have the love and support of others. In conclusion, I enjoyed this movie and I feel this film was very palatable because its characters were well developed and very believable. Its screenplay was written very well and is very realistic. We, as young adults can relate to this film because the issues these children face are the same issues that children in face everyday, and even more so for those who come from the inner city themselves.

Friday, November 8, 2019

After whetting Michael Collins

After whetting Michael Collins and knowing a little more about the things he did and the way he did things it really opened my eyes to the situation in Ireland. I had seen the movie before but after I wrote my policy paper on the IRA and then saw it again I really understood the problems in Ireland. Before I watched the movie for the second time I really saw what Collins was after. I thought that he was some radical terrorist who was 100 percent on the side of the IRA no matter what the sercumstances were. After I saw it again and knew more about him and the IRA he was one of the members of the IRA who was willing to take what the British was offering and work from there. I dont see him as a man who was willing to be in a constant war to receive independence. He was involved in attacks and battles, but I dont think that is what he wanted for the rest of his life and thats why he took the partial independence. What he believed in cost him his life and started a civil war between the IRA and the New Free Irish State. What Collins did was create something positive in a country with no hope or future. He gave his country hope for the future in exchange for his friends and a constant fear for his life. What he did has not stopped what the IRA does or hopes to do but he did! give them something to build on and hopefully to negotiate with the British on something to resolve this never ending battle. I always knew what the IRA was to some extent, but now I think I have the right perspective on what they are. I always thought that they were a group of raging lunatics running around bombing towns and killing people. Now I know they did bomb towns and fight battles for years, but it was for the right to be called an independent country.

Wednesday, November 6, 2019

You Are Essays - Alright, Free Essays, Term Papers, Research Papers

You Are Essays - Alright, Free Essays, Term Papers, Research Papers You Are To you you are nothing To me you are everything To you you are confided To me you are no higher To you you are alright To me you are so bright To you I am everything To me you are everythin To me you are everything Bibliography Dallas crocker cool daddy

Monday, November 4, 2019

Albert Pope, Columbia Bicycles, and Mass Production Assignment

Albert Pope, Columbia Bicycles, and Mass Production - Assignment Example Pope’s response reflects the American capitalist culture which emphasizes that individual ability and inventiveness are the bedrock of successful businesses. 8. Pope held that the US produced bicycles of superior quality and more profitability than Britain due to the absence of labor unions, facilitating the introduction of labor saving machines and cutting down on the number of employees. 9. The Fordist factory shows specialized departments, vertical integration and large volume of manufacture. Flexible firms are vertically disintegrated, have no specialization, and employ geographically scattered labor. Pope’s factory was concentrated geographically into one industrial complex; there were specialized departments for the manufacture of various components; vertically integration was emphasized, with Pope buying out his suppliers, such as the Weed Sewing Machine Company and the Hartford Rubber Works. In addition to innovation in bicycle parts, Pope adopted innovations in the production process, such as stamping and pressing methods, cold drawn steel, case hardening, swaging, annealing, electric welding, and die making. 15. The ownership of valuable patents constituted assets for the company; competition led to investment in technological innovation and industrial espionage; rapid innovation in technology made older models obsolete. 25. In order to promote the use of bicycles by women, Pope attempted to overcome the obstacle posed by the lack of socially accepted, appropriate dress for women cyclists. By donating $ 100 for a competition at the elitist Waldorf Hotel for the best doll in a cycling costume, Pope promoted cycling among the upper classes, secured a socially-sanctioned bicycling costume and received favorable publicity. 26. Pope countered church criticism of bicycling on Sundays by portraying cycling as a means of exercise leading to good health, and therefore meriting divine approval. He also indicated that

Saturday, November 2, 2019

Lack of communication between students and academic advisors Essay

Lack of communication between students and academic advisors - Essay Example First, students are not assigned to ‘individual advisors’; in other words, they keep on changing advisors as the course of their study progresses; hence, the problem crops up as a result of inconsistent communication. For sure, there are differences in advising strategies from one advisor to another so once a student is not being assigned to his or her individual advisor throughout the entire duration of the study, it only blurs the approaches that students will have to implement in their studies. Second is record keeping: the downside of having to be assigned to various teachers is the lack of constant communication and the disarray of record-keeping. As aforementioned, each advisor has varying counseling and advising strategies; and this only cause nothing but potential confusion on the part of the student. Because they are not assigned to a single advisor, chances are they are not going to develop a singular approach towards their study or research. And that is aside from the fact that they do not get to meet their advisor on a permanent basis. Lastly, the issues on policies whether to employ individual advising or one on one advising or not only exacerbate the situation: academic institutions should be able to address this concern once and for all. Lack of communication between students and advisors is a result of inconsistency of meetings between students and advisors. If we can get the students assigned to a single advisor throughout the entire duration of their study, then there is a greater chance that they will be able to complete their degrees; but again, the decision entirely depends on the policies of the schools. The above argument proves that each student should be given a separate student and not a horde of people who just care to get done with their work without much caring about the probable outcomes of their research. Coming to our main issue, dealing with the biased attitude towards students that are not assigned to individual ad visors. Coming to other questions which state that since this is such a small proportion of people so why such big enforcements are needed? The answer is that they are citizens too and thence it is their right to have everything that is destined for them. Though, this is agreed that there are laws for the disabled but how many people respect them? And how many universities; both private and state universities, follow the instructions laid down by the ADA act? So the duty falls upon the fellow students to minimize their biases and help push the implementation of policies that encourage assignment to individual advisors. Contentions on Policy Changes One particular reason as to why assigning students to individual advisors cannot be carried out is that the student to teacher ratio suggests it cannot be done. Well, that is if the intention is to assign one student per advisor and that is it. However, assignment of students to individual advisors should not be defined by claiming the en tire exclusivity of the advisor for the students advising needs for the entire duration of the study. The point is that students needs to have â€Å"